RESUMEN
Objective To study the expression of distintegrin and metalloprotease (ADAM10) in serum of lung cancer patients and its clinical significance. Methods The serum protein level of ADAM10 was assayed by ELISA in 44 lung cancer patients,34 benign lung lesions and 31 healthy subjects. The serum protein level of CEA was assayed by radioimmunoassay. Results The serum concentration of ADAM10 and CEA was higher in patients with lung cancer than benign lung lesions and normal controls(P <0.01) ,theft was distinct statistical difference be-tween lung cancer and lung benign lesions,normal controls(P <0.01) ,but no statistical difference between lung be-nign lesions and normal controls(P >0.05) ; the serum concentration of ADAM10 of lung cancer with lymph node metastasis were significantly higher than those of lung cancer without lymph node metastasis, there was statistical difference (P < 0.01) ; the serum concentration of CEA of lung cancer with lymph node metastasis were slightly higher than those of lung cancer without lymph node metastasis, but there was no difference (P > 0.05) ; the serum concentration of ADAM10 and CEA in adenocarcinoma were higher than squamous cell carcinoma and small cell lung cancer(P <0.01 ,P <0.05). The single item detection of ADAM10 or CEA to the lung cancer diagnostic sensitivity is 51.7% ,56.9% respectively,the union detection reaches 84.5% . Conclusion ADAM10 is related with occur-rence and metastasis in lung cancer. The union detection of ADAM10 and CEA can raise the lung cancer diagnostic sensitivity.
